The Medicinal Chemistry Divisions of the two Belgian Chemical Societies, Koninklijke Vlaamse Chemische Vereniging (KVCV) and Soci茅t茅 Royale de Chimie (SRC), are organising every year an international one-day symposium in Belgium, with the aim to update participants on selected areas of pharmaceutical research by specialists in their respective field.
In recent years, this symposium has been gathering every year around 170 participants, half from universities, half from industry, both from Belgium and surrounding countries. It has been focussing on topics such as "PET & Imaging : From Chemistry Lab to Clinical Applications" (2016); "New Vistas in GPCR Research: the Dawn of an Exciting Drug Discovery Era?" (2014); 鈥淐onstrained Peptides and Macrocycles 鈥� New Opportunities for Drug Discovery鈥� (2013); 鈥淔rom Rapid Dissociation to Irreversible Inhibition 鈥� Optimisation of Drug-Target Residence Time鈥� (2012); 鈥淓merging Targets and Treatments: Opportunities and Challenges for Drug Design鈥� (2011); 鈥淒oes size matter? Beyond small molecule therapeutics: challenges and success stories鈥� (2009); 鈥淪mall molecules, Antibodies and Natural Products: Multiple Faces of Medicinal Chemistry鈥� (2008); or 鈥淣ew Drugs and Drug Candidates: Recent Achievements in Medicinal Chemistry (2007)鈥�.
The objective of the one-day symposium is to delve into the latest developments of the applications of nucleosides, nucleotides and nucleic acids in medicinal chemistry. In the past, the applications where situated mainly in the fields of antivirals, anticancer compounds and antisense oligonucleotides. More recently, new therapeutic applications, for example in immune-oncology, and the discovery of new functions of nucleic acids in the cell such as siRNA, Crispr/Cas together with new breakthroughs in in vitro selection technologies (XNA aptamers), have revived the field and have opened many new possibilities for drug design. The present knowledge in these different research areas will be presented during the symposium.
In recent years, this symposium has been gathering every year around 170 participants, half from universities, half from industry, both from Belgium and surrounding countries. It has been focussing on topics such as "PET & Imaging : From Chemistry Lab to Clinical Applications" (2016); "New Vistas in GPCR Research: the Dawn of an Exciting Drug Discovery Era?" (2014); 鈥淐onstrained Peptides and Macrocycles 鈥� New Opportunities for Drug Discovery鈥� (2013); 鈥淔rom Rapid Dissociation to Irreversible Inhibition 鈥� Optimisation of Drug-Target Residence Time鈥� (2012); 鈥淓merging Targets and Treatments: Opportunities and Challenges for Drug Design鈥� (2011); 鈥淒oes size matter? Beyond small molecule therapeutics: challenges and success stories鈥� (2009); 鈥淪mall molecules, Antibodies and Natural Products: Multiple Faces of Medicinal Chemistry鈥� (2008); or 鈥淣ew Drugs and Drug Candidates: Recent Achievements in Medicinal Chemistry (2007)鈥�.
The objective of the one-day symposium is to delve into the latest developments of the applications of nucleosides, nucleotides and nucleic acids in medicinal chemistry. In the past, the applications where situated mainly in the fields of antivirals, anticancer compounds and antisense oligonucleotides. More recently, new therapeutic applications, for example in immune-oncology, and the discovery of new functions of nucleic acids in the cell such as siRNA, Crispr/Cas together with new breakthroughs in in vitro selection technologies (XNA aptamers), have revived the field and have opened many new possibilities for drug design. The present knowledge in these different research areas will be presented during the symposium.
