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Lead-Oriented Synthesis: Exploring Drug-Relevant Chemical Diversity

25 September 2015, Stevenage, United Kingdom


Introduction
The ready availability of structurally novel lead molecules with appropriately controlled molecular properties (e.g. logP, molecular weight and fraction of sp3 atoms) is crucial to the ability of the pharmaceutical industry to bring new small molecule drugs to market. However, it is now recognised that access to such lead molecules is poorly served not only by many current commercial libraries but also by the synthetic methods widely adopted within industry and many of those developed in academic laboratories. In this meeting, approaches to rectifying this issue will be presented both from academia and industry, with the hope of stimulating a broader recognition of, and solutions to, the challenges of lead-oriented synthesis.
Speakers
  • Prof. Jeffrey Bode ETH Zurich, Switzerland
  • Dr Ian Churcher GSK, United Kingdom
  • Dr Jason Kettle AstraZeneca, United Kingdom
  • Prof. Steve Marsden University of Leeds, United Kingdom
  • Prof. Peter O'Brien University of York, United Kingdom
  • Prof. David Spring University of Cambridge, United Kingdom

Venue
GSK Stevenage

GSK Stevenage, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom

Organised by
EPSRC Dial-a-Molecule Grand Challenge Network
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