Nitric oxide (NO), generated by the enzyme nitric oxide synthase (NOS) plays a key role in a diverse range of physiological and pathophysiological conditions within the cardiovascular, immune, reproductive and nervous systems. This meeting will examine the role of NO in neurodegenerative diseases such as Parkinson's and Alzheimer's diseases, endothelial function/dysfunction, cancer, diabetes and infection. Specific attention will be given to the methodology used by investigators to examine the roles of NO in health and disease.