Crystallisation has been described as one of the most difficult unit operations to control. This is partly because the primary nucleation event, particularly in batch crystallisers, is difficult to control reproducibility without seeding, partly because secondary nucleation processes which result are highly scale and process dependent
and partly because of the delicate balance between thermodynamic and kinetic factors in crystallisation processes which operate far from equilibrium. The consequence of these features can be poor reproducibility of purity, particle size distribution, morphology and crystal structure.
and partly because of the delicate balance between thermodynamic and kinetic factors in crystallisation processes which operate far from equilibrium. The consequence of these features can be poor reproducibility of purity, particle size distribution, morphology and crystal structure.
