Synopsis
This is the sixth one day event organised by SCIs Young Chemists Panel to highlight the challenges associated with ADMET (Absorption, Distribution, Metabolism, Elimination and Toxicity) in medicinal chemistry. The aim of the day is to provide participants with a practical understanding of ADMET parameters, how to diagnose common ADMET problems and how to improve compound design to overcome these problems. Topics will include how to identify problems with solubility, permeability, clearance, duration and chemical-related toxicology; how to interpret data from commonly used non-efficacy tests; and real life examples of solutions to ADMET problems.
Programme
To download the flyer, click here.
09.15
Registration and refreshments
09.55
Introduction and welcome
10.00
Absorption
Practical understanding of concepts & parameters
How do you know you have a problem?
Sources of problem Solubility, Permeability, PGP Efflux
Chemical strategies to improve absorption
Worked examples
11.15
Refreshment break
11.45
Metabolism and clearance I
Practical understanding of concepts & parameters
How do you know you have a problem?
Sources of problem - Phase I / Phase II Metabolism
Chemical strategies to address metabolism
Worked examples
13.00
Lunch
14.15
Metabolism and clearance II
Cytochrome P450s and Drug-Drug interactions
Volume of distribution how to understand and influence
Plasma protein binding impact & influence
Worked examples
15.45
Refreshment break
16.15
Drug toxicity and toxicology
Context & common issues
Design strategies to mitigate risks of hERG, phospholipidosis, reactive
metabolites & genotoxicity
17.15
Summary and closing remarks
17.30
Wine reception
Exhibition
An exhibition will take place alongside the conference during refreshment breaks for companies and related organisations who may wish to exhibit. For further information and prices, please email conferences@soci.org. Spaces are limited and will be allocated on a first come, first served basis.
Delegate Fees
Earlybird fees - before 13 April 2015
GB贈115 .................................SCI Member
GB贈40 ...................................SCI Student
GB贈80 ...................................Subsidised Member
GB贈170 ................................ Non-Member
Standard fees - after 13 April 2015
GB贈140 .................................SCI Member
GB贈50 ...................................SCI Student
GB贈100 .................................Subsidised Member
GB贈205 .................................Non-Member
This is the sixth one day event organised by SCIs Young Chemists Panel to highlight the challenges associated with ADMET (Absorption, Distribution, Metabolism, Elimination and Toxicity) in medicinal chemistry. The aim of the day is to provide participants with a practical understanding of ADMET parameters, how to diagnose common ADMET problems and how to improve compound design to overcome these problems. Topics will include how to identify problems with solubility, permeability, clearance, duration and chemical-related toxicology; how to interpret data from commonly used non-efficacy tests; and real life examples of solutions to ADMET problems.
Programme
To download the flyer, click here.
09.15
Registration and refreshments
09.55
Introduction and welcome
10.00
Absorption
Practical understanding of concepts & parameters
How do you know you have a problem?
Sources of problem Solubility, Permeability, PGP Efflux
Chemical strategies to improve absorption
Worked examples
11.15
Refreshment break
11.45
Metabolism and clearance I
Practical understanding of concepts & parameters
How do you know you have a problem?
Sources of problem - Phase I / Phase II Metabolism
Chemical strategies to address metabolism
Worked examples
13.00
Lunch
14.15
Metabolism and clearance II
Cytochrome P450s and Drug-Drug interactions
Volume of distribution how to understand and influence
Plasma protein binding impact & influence
Worked examples
15.45
Refreshment break
16.15
Drug toxicity and toxicology
Context & common issues
Design strategies to mitigate risks of hERG, phospholipidosis, reactive
metabolites & genotoxicity
17.15
Summary and closing remarks
17.30
Wine reception
Exhibition
An exhibition will take place alongside the conference during refreshment breaks for companies and related organisations who may wish to exhibit. For further information and prices, please email conferences@soci.org. Spaces are limited and will be allocated on a first come, first served basis.
Delegate Fees
Earlybird fees - before 13 April 2015
GB贈115 .................................SCI Member
GB贈40 ...................................SCI Student
GB贈80 ...................................Subsidised Member
GB贈170 ................................ Non-Member
Standard fees - after 13 April 2015
GB贈140 .................................SCI Member
GB贈50 ...................................SCI Student
GB贈100 .................................Subsidised Member
GB贈205 .................................Non-Member
